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Image Search Results
Journal: Nature genetics
Article Title: Genetic variants at CD28 , PRDM1 , and CD2/CD58 are associated with rheumatoid arthritis risk
doi: 10.1038/ng.479
Figure Lengend Snippet: SNPs tested for RA susceptibility The first 6 columns list SNP characteristics. The next four columns list GWA meta-analysis results including allele frequencies, a two-tailed p -value for SNP association, and an odds ratio (OR) with respect to the minor allele. The next four columns list similar results for replication genotyping; significance is reported based on stratified one-tailed CMH statistic. The next three columns summarize joint (overall) analysis results. Significance is reported based on stratified two-tailed CMH statistic across all fourteen patient collections. The final column lists the Breslow-Day Test for heterogeneity of odds ratios across all fourteen collections (3 from the meta-analysis and 11 from the replication study).
Article Snippet: We genotyped replication samples at the Broad Institute using a single Sequenom iPlex Pool (for EIRA-II and GENRA collections) and Affymetrix 6.0 (BRASS), the National Institutes of Health using a single Sequenom iPlex Pool (NARAC-II), Analytic Genetics Technology Centre in Toronto using a single Sequenom iPlex Pool (CANADA-II), Epidemiology Unit at The University of Manchester using a single Sequenom iPlex Pool (UKRAG), Celera using kinetic PCR (GCI and LUMC), at the Nurses Health Study in Boston using the
Techniques: Control